Now showing items 1-10 of 25
Characterization of the Ornithine Hydroxylation Step in Albachelin Biosynthesis
<i>N</i>-Hydroxylating monooxygenases (NMOs) are involved in siderophore biosynthesis. Siderophores are high affinity iron chelators composed of catechol and hydroxamate functional groups that are synthesized and secreted ...
Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest
(Amer Chemical Soc, 2015-07-01)
Citrulination unravels stem cells
The Quest for a Simple Bioactive Analog of Paclitaxel as a Potential Anticancer Agent
(Amer Chemical Soc, 2014-08-01)
Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors
Successful medicinal chemistry campaigns to discover and optimize sphingosine kinase inhibitors require a robust assay for screening chemical libraries and for determining rank order potencies. Existing assays for these ...
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of ...
Transition metal diamine complexes with antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA)
(Royal Society of Chemistry, 2015-06)
Pentaalkylcyclopentadienyl (Cp*R) iridium (Ir) and cobalt (Co) 1,2-diamine complexes were synthesized. Susceptibility of Staphylococcus aureus and recent patient methicillin-resistant S. aureus (MRSA) isolates to the ...
Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.
(Amer Chemical Soc, 2014-05-16)
The new triterpene turranoic acid (1) and thenew N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak ...
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient ...