Now showing items 11-20 of 36
Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest
(Amer Chemical Soc, 2015-07-01)
Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.
(Amer Chemical Soc, 2014-05-16)
The new triterpene turranoic acid (1) and thenew N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak ...
The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats
Allen and Pennington et al. show that the cardiolipin-binding peptide elamipretide mitigates disease-induced fragmentation of cristae networks following cardiac ischemia reperfusion in rats. This study suggests that ...
A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications
(Taylor & Francis Inc, 2015-03-01)
The lack of a rapid and quantitative autophagy assay has substantially hindered the development and implementation of autophagy-targeting therapies for a variety of human diseases. To address this critical issue, we developed ...
Structural, in silico, and functional analysis of a Disabled-2-derived peptide for recognition of sulfatides
Disabled-2 (Dab2) is an adaptor protein that regulates the extent of platelet aggregation by two mechanisms. In the first mechanism, Dab2 intracellularly downregulates the integrin alpha (IIb)beta (3) receptor, converting ...
High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB
The bacterial type IV pilus (T4P) is a prominent virulence factor in many significant human pathogens, some of which have become increasingly antibiotic resistant. Antivirulence chemotherapeutics are considered a promising ...
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of ...
Safety of drug use in patients with a primary mitochondrial disease: An international Delphi-based consensus
Clinical guidance is often sought when prescribing drugs for patients with primary mitochondrial disease. Theoretical considerations concerning drug safety in patients with mitochondrial disease may lead to unnecessary ...
Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage
Background The continuum of pro- and anti-inflammatory response elicited by traumatic brain injury (TBI) is suggested to play a key role in the outcome of TBI; however, the underlying mechanisms remain ill -defined. Methods Here, ...
Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
(United States Patent and Trademark Office, 1995-11-28)
The natural product cephalomannine can be converted to the important anticancer natural product taxol by a simple process involving the steps of dihydroxylation to give cephalomannine-diols, diol cleavage, benzoylation at ...