Scholarly Works, Virginia Tech Carilion School of Medicine (VTCSOM)
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Research articles, presentations, and other scholarship
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NLRX1 Is a Multifaceted and Enigmatic Regulator of Immune System Function
(2019-10-11)Over the last decade, significant progress has been achieved in defining mechanisms underlying NLR regulation of immune system function. However, several NLR family members continue to defy our best attempts at characterization ... -
Drug-Susceptible and Multidrug-Resistant Mycobacterium tuberculosis in a Single Patient
(2019-11)A patient who had initial infection with mixed strains of drug-susceptible and multidrug-resistant tuberculosis was presumed to have acquired drug resistance before confirmation that sequential strains were genotypically ... -
Multimodal Imaging of Nonenhancing Glioblastoma Regions
(2019-11-13)Background: Clinical glioblastoma treatment mostly focuses on the contrast-enhancing tumor mass. Amino acid positron emission tomography (PET) can detect additional, nonenhancing glioblastoma-infiltrated brain regions that ... -
Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid
(2020-01-20)Abstract Background The clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of the utility of CRISPR–Cas9 for in ... -
Laparoscopic repair of interparietal abdominal wall hernias
(Oxford University Press, 2019-10-01)Interparietal hernias are rare abdominal defects where intraabdominal contents protrude between layers of the abdominal wall. There is limited experience using laparoscopic technique for repairing substantially large ... -
Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix)
(PLOS, 2019-09-27)Raman chemometric urinalysis (Rametrix™) was used to analyze 235 urine specimens from healthy individuals. The purpose of this study was to establish the “range of normal” for Raman spectra of urine specimens from healthy ... -
Simultaneous involvement of optic and abducens nerves by Lyme disease: Case report with review of the literature
(PAGEPress, 2019)Ocular manifestations of Lyme disease (LD) remain a rare feature of the disease, but it may present a wide range of clinical presentations with different combinations. LD related optic neuritis or cranial nerve (CN) six ... -
Atypical presentation of Lyme neuroborreliosis related meningitis and radiculitis
(PAGEPress, 2019-10-11)Lyme disease related central and peripheral nervous system manifestations can occur in isolation or together. Radiculitis or inflammation of the nerve root can be seen 3-5% of the time in acute neuroborreliosis affecting ... -
Diagnosis and Treatment of a Benign Pediatric Mandible Tumor
(Ovid Technologies, 2019-10-15)Pediatric mandible tumors are rare and generally benign but can be locally aggressive. Diagnosis and treatment involve tumor identification, excision, and subsequent reconstruction. Successful reconstruction should address ... -
Metastatic Multiple Myeloma to the Skin
(Hindawi, 2019-11-12)Cutaneous involvement of multiple myeloma (MM) is uncommon, typically occurs in late stage disease, and is a poor prognostic indicator with an approximate eight month median survival. We present a 51-year-old man with ... -
Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor
(Hindawi, 2019-12-05)Follicular dendritic cell sarcoma (FDCS) is a rare and underdiagnosed malignant neoplasm which characteristically presents as a solitary, slow-growing mass with no discrete symptoms. Histologically, lymphocytes and spindle ... -
Epidermoid Cysts in a Wandering Spleen: An Unusual Enigma
(Hindawi, 2019-11-20)Epidermoid splenic cysts are rare lesions in the spleen. These cysts are characterized by a stratified squamous epithelial lining, internal septations, and calcification. Congenital in origin, epidermoid splenic cysts are ... -
Dropped head syndrome due to neuromuscular disorders: Clinical manifestation and evaluation
(PAGEPress, 2019-06-18)In this article, we discuss the clinical approach to patients with dropped head syndrome and identify the various neuromuscular causes of dropped head syndrome including muscle, neuromuscular junction, peripheral nerve and ... -
The development of myasthenia gravis in a patient with facioscapulohumeral muscular dystrophy: case report and literature review
(PAGEPress, 2019-06-10)The co-existence of facioscapulohumeral muscle dystrophy (FSHD) and myasthenia gravis (MG) is very rare and few cases have been described in the literature. To increase the awareness of the health care providers, we present ... -
A Genetic System for Methanocaldococcus jannaschii: An Evolutionary Deeply Rooted Hyperthermophilic Methanarchaeon
(Frontiers, 2019-07-03)Phylogenetically deeply rooted methanogens belonging to the genus of Methanocaldococcus living in deep-sea hydrothermal vents derive energy exclusively from hydrogenotrophic methanogenesis, one of the oldest respiratory ... -
Formation of the Francisella tularensis Biofilm is Affected by Cell Surface Glycosylation, Growth Medium, and a Glucan Exopolysaccharide
(Springer Nature, 2019-08-22)Biofilms are matrix-associated communities that enable bacteria to colonise environments unsuitable for free-living bacteria. The facultative intracellular pathogen Francisella tularensis can persist in water, amoebae, and ... -
IL-12 signaling drives the differentiation and function of a T(H)1-derived T-FH1-like cell population
(Springer Nature, 2019-09-30)CD4(+) T follicular helper (T-FH) cells provide help to B cells and promote antibody-mediated immune responses. Increasing evidence supports the existence of T-FH populations that secrete cytokines typically associated ... -
Proteogenomic Analysis of Protein Sequence Alterations in Breast Cancer Cells
(Nature Research, 2019-07-18)Cancer evolves as a result of an accumulation of mutations and chromosomal aberrations. Developments in sequencing technologies have enabled the discovery and cataloguing of millions of such mutations. The identification ... -
Neural computations underlying social risk sensitivity
(Frontiers, 2012-08-02)Under standard models of expected utility, preferences over stochastic events are assumed to be independent of the source of uncertainty. Thus, in decision-making, an agent should exhibit consistent preferences, regardless ... -
Plant-Produced Asialo-Erythropoietin Restores Pancreatic Beta-Cell Function by Suppressing Mammalian Sterile-20-like Kinase (MST1) and Caspase-3 Activation
(Frontiers, 2017-04-19)Pancreatic beta-cell death adversely contributes to the progression of both type I and II diabetes by undermining beta-cell mass and subsequently diminishing endogenous insulin production. Therapeutics to impede or even ...
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