Scholarly Works, Virginia Tech Carilion School of Medicine (VTCSOM)
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Research articles, presentations, and other scholarship
Recent Submissions
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Demographic Trends in Paddle Lead Spinal Cord Stimulator Placement: Private Insurance and Medicare Beneficiaries
(2020-06)Objective: Although spinal cord stimulators (SCS) continue to gain acceptance as a viable nonpharmacologic option for the treatment of chronic back pain, recent trends are not well established. The aim of this study was ... -
Eagle Syndrome: A Rare Case of Atraumatic, Painful Cervical Neck Swelling
(Western Journal of Emergency Medicine, 2020-04-23)Introduction: Painful neck swelling is a common emergency complaint but can present diagnostic challenges. Eagle syndrome is a rare clinical entity in which a pathologically elongated styloid process or ossified stylohyoid ... -
Pleural lipomatosis: An often-forgotten intrathoracic tumor
(Elsevier, 2020-04-30)Lipomas are benign mesenchymal neoplasms that arise from adipocytes. Most lipomas are found in the subcutaneous tissue; however, they can be present throughout the body. Lipomas arising from the thoracic pleura are ... -
A case series of endemic infections associated hemophagocytic lymphohistiocytosis (HLH) mimicking severe sepsis syndrome
(Elsevier, 2019-05-06)Hemophagocytic lymphohistiocytosis (HLH) is associated to high mortality and morbidity. A condition often underrecognized, HLH should be in the differential diagnosis of patients presenting with fever, cytopenia, ... -
VTCSOM Medical Student Research Symposium 2020
(Virginia Tech Carilion School of Medicine, 2020-03-27)A program for the medical student research symposium, held virtually on March 27, 2020. -
Characterization of Ablation Thresholds for 3D-Cultured Patient-Derived Glioma Stem Cells in Response to High-Frequency Irreversible Electroporation
(American Association for the Advancement of Science, 2019-04-28)High-frequency irreversible electroporation (H-FIRE) is a technique that uses pulsed electric fields that have been shown to ablate malignant cells. In order to evaluate the clinical potential of H-FIRE to treat glioblastoma ... -
Diverse GABAergic neurons organize into subtype-specific sublaminae in the ventral lateral geniculate nucleus
(Wiley, 2020-05-19)In the visual system, retinal axons convey visual information from the outside world to dozens of distinct retinorecipient brain regions and organize that information at several levels, including either at the level of ... -
Filtration evaluation and clinical use of expired elastomeric P-100 filter cartridges during the COVID-19 pandemic
(Cambridge University Press, 2020-05-27)To the Editor—The limited supply of more conventional disposable personal protective equipment (PPE), namely single-use N95 filtering facepiece respirators (FFRs), among hospital systems in the United States during the ... -
Spontaneous necrotizing granuloma of the cerebellum: a case report
(2020-06-05)Abstract Background Intracranial necrotizing granulomatous space-occupying lesions are sparsely reported in literature. Variability in presenting symptomatology and radiographic features makes diagnostic work-up ... -
A Case of Cachexia Secondary to Obsessive-Compulsive Disorder
(Hindawi, 2020-05-27)Obsessive-compulsive disorder (OCD), a relatively common psychiatric illness, is diagnosed using DSM-V criteria. Its severity is assessed using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Symptoms are broken down ... -
Practice facilitation to promote evidence-based screening and management of unhealthy alcohol use in primary care: a practice-level randomized controlled trial
(2020-05-20)Abstract Background Unhealthy alcohol use is the third leading cause of preventable death in the United States. Evidence demonstrates that screening for unhealthy alcohol use and providing persons engaged in risky drinking ... -
Structural Neural Connectivity Analysis in Zebrafish With Restricted Anterograde Transneuronal Viral Labeling and Quantitative Brain Mapping
(2020-01-23)The unique combination of small size, translucency, and powerful genetic tools makes larval zebrafish a uniquely useful vertebrate system to investigate normal and pathological brain structure and function. While functional ... -
Persistent Feeding and Swallowing Deficits in a Mouse Model of 22q11.2 Deletion Syndrome
(2020-01-31)Disrupted development of oropharyngeal structures as well as cranial nerve and brainstem circuits may lead to feeding and swallowing difficulties in children with 22q11. 2 deletion syndrome (22q11DS). We previously ... -
Cost-Effectiveness of Risk-Stratified Colorectal Cancer Screening Based on Polygenic Risk: Current Status and Future Potential
(2020-02)Background: Although uniform colonoscopy screening reduces colorectal cancer (CRC) mortality, risk-based screening may be more efficient. We investigated whether CRC screening based on polygenic risk is a cost-effective ... -
Opioids and Spinal Cord Stimulators: Pre- and Postoperative Opioid Use Patterns and Predictors of Prolonged Postoperative Opioid Use
(2020-03)Objective: The aim of the study was to compare trends and differences in preoperative and prolonged postoperative opioid use following spinal cord stimulator (SCS) implantation and to determine factors associated with ... -
Postoperative Anemia Predicts Length of Stay for Geriatric Patients Undergoing Minimally Invasive Lumbar Spine Fusion Surgery
(2020-03-31)Introduction: We hypothesize that postoperative anemia will predict length of stay (LOS) for geriatric patients undergoing minimally invasive (MIS) lumbar spine fusions. Materials and Methods: Patients who underwent MIS ... -
Non-Cell Autonomous Roles for CASK in Optic Nerve Hypoplasia
(ARVO, 2019)PURPOSE. Heterozygous mutations in the essential X-linked gene CASK associate with optic nerve hypoplasia (ONH) and other retinal disorders in girls. CASKþ/ heterozygous knockout mice with mosaic CASK expression exhibit ... -
Translating Translation to Mechanisms of Cardiac Hypertrophy
(MDPI, 2020-03-10)Cardiac hypertrophy in response to chronic pathological stress is a common feature occurring with many forms of heart disease. This pathological hypertrophic growth increases the risk for arrhythmias and subsequent heart ... -
Human Tyrosinase: Temperature-Dependent Kinetics of Oxidase Activity
(MDPI, 2020-01-30)Human tyrosinase (Tyr) is involved in pigment biosynthesis, where mutations in its corresponding gene TYR have been linked to oculocutaneous albinism 1, an autosomal recessive disorder. Although the enzymatic ... -
NLRX1 Is a Multifaceted and Enigmatic Regulator of Immune System Function
(2019-10-11)Over the last decade, significant progress has been achieved in defining mechanisms underlying NLR regulation of immune system function. However, several NLR family members continue to defy our best attempts at characterization ...
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