The presence of substitution among multiple similar products plays an important role in inventory management. It has been observed in the literature that incorporating the impact of substitution among products can substantially improve the profit and reduce the understock or overstock risk. This thesis focuses on exploring and exploiting the impact of substitution on inventory management problems by theoretically analyzing mathematical models and developing efficient solution approaches.

To that end, we address four problems. In the first problem, we study different pricing strategies and the role of substitution for new and remanufactured products.

Our work presents a two-stage model for an original equipment manufacturer (OEM) in this regard. A closed-form one-to-one mapping of product designs onto the optimal product strategies is developed, which provides useful information for the retailer.

Our second problem is a multi-product newsvendor problem with customer-driven demand substitution. We completely characterize the optimal order policy when the demand is known and reformulate this nonconvex problem as a binary quadratic program. When the demand is stochastic, we formulate the problem as a two-stage stochastic program with mixed integer recourse, derive several necessary optimality conditions, prove the submodularity of the profit function, develop polynomial-time approximation algorithms, and show their performance guarantees. Our numerical investigation demonstrates the effectiveness of the proposed algorithms and, furthermore, reveals several useful findings and managerial insights.

In the third problem, we study a robust multi-product newsvendor model with substitution (R-MNMS), where both demand and substitution rates are uncertain and are subject to cardinality-constrained uncertainty set. We show that for given order quantities, computing the worst-case total profit, in general, is NP-hard, and therefore, address three special cases for which we provide closed-form solutions.

In practice, placing an order might incur a fixed cost. Motivated by this fact, our fourth problem extends the R-MNMS by incorporating fixed cost (denoted as R-MNMSF) and develop efficient approaches for its solution. In particular, we propose an exact branch-and-cut algorithm to solve small- or medium-sized problem instances of the R-MNMSF, and for large-scale problem instances, we develop an approximation algorithm. We further study the effects of the fixed cost and show how to tune the parameters of the uncertainty set.