Show simple item record

dc.contributor.authorGraybill, Philip M.en
dc.contributor.authorDavalos, Rafael V.en
dc.date.accessioned2020-05-14T17:47:56Zen
dc.date.available2020-05-14T17:47:56Zen
dc.date.issued2020-04-30en
dc.identifier.citationGraybill, P.M.; Davalos, R.V. Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies. Cancers 2020, 12, 1132.en
dc.identifier.urihttp://hdl.handle.net/10919/98391en
dc.description.abstractPulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the treatment of tumors. PEFs increase the permeability of cell membranes, a phenomenon known as electroporation. In addition to well-known membrane effects, PEFs can cause profound cytoskeletal disruption. In this review, we summarize the current understanding of cytoskeletal disruption after PEFs. Compiling available studies, we describe PEF-induced cytoskeletal disruption and possible mechanisms of disruption. Additionally, we consider how cytoskeletal alterations contribute to cell–cell and cell–substrate disruption. We conclude with a discussion of cytoskeletal disruption-induced anti-vascular effects of PEFs and consider how a better understanding of cytoskeletal disruption after PEFs may lead to more effective therapies.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectpulsed electric fieldsen
dc.subjectelectroporationen
dc.subjectcytoskeletonen
dc.subjectactinen
dc.subjectmicrotubulesen
dc.subjectintermediate filamentsen
dc.subjectcell junctionsen
dc.subjectnsPEFsen
dc.subjectIREen
dc.subjectECTen
dc.subjectmechanobiologyen
dc.subjectvascular locken
dc.subjectcanceren
dc.titleCytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapiesen
dc.typeArticle - Refereeden
dc.date.updated2020-05-14T13:55:59Zen
dc.description.versionPublished versionen
dc.contributor.departmentMechanical Engineeringen
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.title.serialCancersen
dc.identifier.doihttps://doi.org/10.3390/cancers12051132en
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International