The ability to understand occlusion and disocclusion is critical in analyzing motion and forecasting changes. For example, when we see a car gradually blocks our view of a human figure, we know that either the car or the human is moving. We also know that the human behind the car will be visible again if we move to other positions. As many vision-based intelligent systems need to handle and react to visual data with potentially intensive motions, it is therefore beneficial to incorporate the occlusion reasoning into such systems. In this thesis, we study how we can improve the performance of vision-based deep learning models by harnessing the power of occlusion handling. We first visit the problem of optical flow estimation for motion analysis. We present a deep learning module that builds upon occlusion handling methods in classic Computer Vision literature. Our results show performance improvement in occluded regions on standard benchmarks, as well as real-world applications. We then examine the problem of view synthesis for 3D photography. We propose an inpainting method that leverages local color and depth context for novel view synthesis. We validate the proposed inpainting approach with a series of quantitative and qualitative experiments, and demonstrate promising results in predicting plausible content in occluded regions.