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dc.contributor.authorPunareewattana, Korawuthen_US
dc.date.accessioned2011-08-06T16:01:20Z
dc.date.available2011-08-06T16:01:20Z
dc.date.issued1998-03-30en_US
dc.identifier.otheretd-110399-160727en_US
dc.identifier.urihttp://hdl.handle.net/10919/9868
dc.description.abstractInhibited immune responses have been observed following occupational, inadvertent, or therapeutic exposure to chemically diverse xenobiotics. In the present studies, preliminary data were generated showing limited but significant systemic immunotoxicity following low-level topical exposure to the pyrethroid insecticide, permethrin (formerly not considered an immunotoxicant). Permethrin was applied to the shaved dorsal interscapular region of C57Bl/6N mice at doses of 0.5, 1.5, or 5.0 μl/day. The highest of these doses was approximately equal to 215 μg/kg/day, which is about seven times the estimated daily human exposure in individuals wearing permethrin treated clothing for insect protection. Mice were thus exposed to permethrin daily for 10 or 30 consecutive days, or every other day for 7 or 14 exposures. Body weight was not affected by the treatment. However thymic weight was decreased and splenic weight increased 2 days after termination of the topical exposure. Histopathology of immune organs showed no significant changes. Splenic macrophages showed significantly depressed chemiluminescent responses up to 10 days following termination of exposure, but macrophage phagocytic activity was not affected. Cell surface markers of thymocytes, splenocytes and bone marrow cells were not affected. Antibody production as shown by plaque forming cell (PFC) assay decreased significantly at 10 days after dosing termination. Taken together, these data indicate that low-level topical permethrin exposure may produce systemic immunotoxicity.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.relation.haspartkp-thesis.pdfen_US
dc.rightsI hereby grant to Virginia Tech or its agents the right to archive and to make available my thesis or dissertation in whole or in part in the University Libraries in all forms of media, now or hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertation.en_US
dc.subjectPermethrinen_US
dc.subjectPyrethroidsen_US
dc.subjectImmunotoxicityen_US
dc.subjectInsecticidesen_US
dc.subjectRisk assessmenten_US
dc.titleImmune Function Determination in Mice Dermally Exposed to Permethrinen_US
dc.typeThesisen_US
dc.contributor.departmentVeterinary Medical Sciencesen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineVeterinary Medical Sciencesen_US
dc.contributor.committeechairHolladay, Steven D.en_US
dc.contributor.committeememberSmith, Bonnie J.en_US
dc.contributor.committeememberRobertson, John L.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-110399-160727en_US
dc.date.sdate1999-11-03en_US
dc.date.rdate2000-11-05
dc.date.adate1999-11-05en_US


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