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dc.contributor.authorSmith, Sandra Kayen_US
dc.date.accessioned2011-08-06T16:01:34Z
dc.date.available2011-08-06T16:01:34Z
dc.date.issued2004-03-19en_US
dc.identifier.otheretd-05142004-110908en_US
dc.identifier.urihttp://hdl.handle.net/10919/9937
dc.description.abstractRecently, hyperthermia has been investigated as an alternate therapy for the treatment of tumors. The present project explored the feasibility of preferential hyperthermia as a method of treating deep seated tumors. The overall goal of this research was to determine theoretically if preferential heating could be used to attain the desired thermal dose (DTD) for a two cm diameter tumor. The simulations in this work show that, when using a single silicon carbide insert, the model cannot provide enough energy for an entire 2 cm diameter tumor to receive the DTD. However, when using an enhanced design model with multiple (4) silicon carbide inserts, the DTD could be attained in a tumor up to 3.5 cm in diameter. This study involved using the commercially available software package ANSYS 7.0 program to model a spherical 2 cm tumor, assuming the tumor is located in deep tissue with a constant perfusion rate and no major blood vessels nearby. This tumor was placed in the center of a cube of healthy tissue. To achieve the preferential heating of the tumor, a silicon carbide insert was placed in the center of the tumor and microwave energy was applied to the insert (in the form of volumetric heating). The thermal modeling of this system was based on the Pennes Bioheat equation with a maximum temperature limitation of of 80 ºC. The Thermal Dose Analyzer software program was used to evaluate the results of the thermal simulations (from ANSYS) to determine if the DTD had been attained. Additional enhanced design models were also examined. These models include 2 cm and 4 cm tumors with four silicon carbide inserts symmetrically placed about the tumor and a 4 cm tumor model using a single silicon carbide insert with antennae attached to the insert to increase energy distribution to the tumor. The simulations show that only the enhanced design cases with four silicon carbide inserts can achieve the DTD for an entire 2 cm tumor.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.relation.haspartThesis.pdfen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectthermal doseen_US
dc.subjecthyperthemia modelingen_US
dc.subjectpreferential hyperthermiaen_US
dc.titleTheoretical Feasibility Study of Preferential Hyperthermia Using Silicon Carbide Insertsen_US
dc.typeThesisen_US
dc.contributor.departmentMechanical Engineeringen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineMechanical Engineeringen_US
dc.contributor.committeechairScott, Elaine P.en_US
dc.contributor.committeememberThomas, James R. Jr.en_US
dc.contributor.committeememberClark, David E.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-05142004-110908en_US
dc.date.sdate2004-05-14en_US
dc.date.rdate2004-05-25
dc.date.adate2004-05-25en_US


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