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dc.contributor.authorChalcraft, Jenna R.en
dc.contributor.authorCardinal, Linda M.en
dc.contributor.authorWechsler, Perry J.en
dc.contributor.authorHollis, Bruce W.en
dc.contributor.authorGerow, Kenneth G.en
dc.contributor.authorAlexander, Brenda M.en
dc.contributor.authorKeith, Jill F.en
dc.contributor.authorLarson-Meyer, D. Enetteen
dc.date.accessioned2020-08-21T15:03:46Zen
dc.date.available2020-08-21T15:03:46Zen
dc.date.issued2020-07-27en
dc.identifier.citationChalcraft, J.R.; Cardinal, L.M.; Wechsler, P.J.; Hollis, B.W.; Gerow, K.G.; Alexander, B.M.; Keith, J.F.; Larson-Meyer, D.E. Vitamin D Synthesis Following a Single Bout of Sun Exposure in Older and Younger Men and Women. Nutrients 2020, 12, 2237.en
dc.identifier.urihttp://hdl.handle.net/10919/99816en
dc.description.abstractOlder adults are frequently cited as an at-risk population for vitamin D deficiency that may in part be due to decreased cutaneous synthesis, a potentially important source of cholecalciferol (vitamin D3). Previous studies found that cutaneous D3 production declines with age; however, most studies have been conducted ex vivo or in the photobiology lab. The purpose of this study was to characterize the response of vitamin D metabolites following a 30-min bout of sun exposure (15-min each to the dorsal and ventral sides) at close to solar noon in younger and older adults. Methods: 30 healthy individuals with skin type II/III were recruited; a younger cohort, aged 20–37 (n = 18) and an older cohort (n = 12), age 51–69 years. Exposure was at outer limits of sensible sun exposure designed to enhance vitamin D synthesis without increasing risk of photo ageing and non-melanoma skin cancer. Serum D3 concentration was measured at baseline, 24, 48 and 72 h post-exposure. Serum 25(OH)D was measured at baseline and 72 h post-exposure plus 168 h post-exposure in the older cohort. Results: D3 increased in response to sun exposure (time effect; p = 0.002) with a trend for a difference in D3 between cohorts (time*group; p = 0.09). By regression modeling of continuous data, age accounted for 20% of the variation in D3 production. D3 production decreased by 13% per decade. Despite changes in D3, however, serum 25(OH)D did not change from baseline to 72 or 168 h post exposure (p > 0.10). Conclusions: Serum D3 concentration increased significantly in response to outdoor sun exposure in younger and older adults. While ageing may dampen cutaneous synthesis, sunlight exposure is still a significant source of vitamin D3.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleVitamin D Synthesis Following a Single Bout of Sun Exposure in Older and Younger Men and Womenen
dc.typeArticle - Refereeden
dc.date.updated2020-08-21T13:49:22Zen
dc.contributor.departmentHuman Nutrition, Foods & Exerciseen
dc.title.serialNutrientsen
dc.identifier.doihttps://doi.org/10.3390/nu12082237en
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen


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