A Potential Role for Pro-Inflammatory Cytokines in the Development of Insulin Resistance in Horses

dc.contributor.authorSuagee, Jessica K.en
dc.contributor.authorCorl, Benjamin A.en
dc.contributor.authorGeor, Raymond J.en
dc.contributor.departmentDairy Scienceen
dc.date.accessed2014-01-06en
dc.date.accessioned2014-01-15T14:16:33Zen
dc.date.available2014-01-15T14:16:33Zen
dc.date.issued2012-05-02en
dc.description.abstractUnderstanding the mechanisms involved in the development of insulin resistance in horses should enable development of effective treatment and prevention strategies. Current knowledge of these mechanisms is based upon research in obese humans and rodents, in which there is evidence that the increased production of pro-inflammatory cytokines by adipose tissue negatively influences insulin signaling in insulin-responsive tissues. In horses, plasma concentrations of the cytokine, tumor necrosis factor-_, have been positively correlated with body fatness and insulin resistance, leading to the hypothesis that inflammation may reduce insulin sensitivity in horses. However, little evidence has documented a tissue site of production and a direct link between inflammation and induction of insulin resistance has not been established. Several mechanisms are reviewed in this article, including the potential for macrophage infiltration, hyperinsulinemia, hypoxia, and lipopolysaccharide to increase pro-inflammatory cytokine production by adipose tissue of obese horses. Clearly defining the role of cytokines in reduced insulin sensitivity of horses will be a very important step in determining how obesity and insulin resistance are related.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSuagee, Jessica K.; Corl, Benjamin A.; Geor, Raymond J. A Potential Role for Pro-Inflammatory Cytokines in the Development of Insulin Resistance in Horses, Animals 2012, 2(2), 243-260; doi:10.3390/ani2020243.en
dc.identifier.doihttps://doi.org/10.3390/ani2020243en
dc.identifier.issn2076-2615en
dc.identifier.urihttp://hdl.handle.net/10919/24831en
dc.identifier.urlhttp://www.mdpi.com/2076-2615/2/2/243en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectadipose tissueen
dc.subjecthorsesen
dc.subjectinflammationen
dc.subjectObesityen
dc.subjectpro-inflammatory cytokinesen
dc.subjectskeletal muscleen
dc.titleA Potential Role for Pro-Inflammatory Cytokines in the Development of Insulin Resistance in Horsesen
dc.title.serialAnimalsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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