Liao, XiaofengPirapakaran, TharshikhaLuo, Xin M.2017-09-182017-09-182016-06-14Xiaofeng Liao, Tharshikha Pirapakaran, and Xin M. Luo, “Chemokines and Chemokine Receptors in the Development of Lupus Nephritis,” Mediators of Inflammation, vol. 2016, Article ID 6012715, 15 pages, 2016. doi:10.1155/2016/6012715http://hdl.handle.net/10919/78933Lupus nephritis (LN) is a major cause of morbidity and mortality in the patients with systemic lupus erythematosus (SLE), an autoimmune disease with damage to multiple organs. Leukocyte recruitment into the inflamed kidney is a critical step to promote LN progression, and the chemokine/chemokine receptor system is necessary for leukocyte recruitment. In this review, we summarize recent studies on the roles of chemokines and chemokine receptors in the development of LN and discuss the potential and hurdles of developing novel, chemokine-based drugs to treat LN.application/pdfenCreative Commons Attribution 4.0 InternationalArticle - Refereed2017-09-18Copyright © 2016 Xiaofeng Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://doi.org/10.1155/2016/6012715