2016-08-242016-08-242007-05-22http://hdl.handle.net/10919/72561Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject.application/pdfen-USPatenthttp://pimg-fpiw.uspto.gov/fdd/18/207/072/0.pdf10485696435/69.1435/320.1435/325435/455514/13.7800/4800/7800/8800/14800/17A61K38/36A61K38/27A61K38/4846A61K48/00C12N2799/022C12N2799/025C12N2799/0277220718