Negative functional coupling between the right fronto-parietal and limbic resting state networks predicts increased self-control and later substance use onset in adolescence

Lee, Tae-HoTelzer, Eva H.2018-09-132018-09-132016-06-17http://hdl.handle.net/10919/85008Recent developmental brain imaging studies have demonstrated that negatively coupled prefrontal-limbic circuitry implicates the maturation of brain development in adolescents. Using resting-state functional magnetic resonance imaging (rs-fMRI) and independent component analysis (ICA), the presentstudy examined functional network coupling between prefrontal and limbic systems and links toself-control and substance use onset in adolescents. Results suggest that negative network coupling(anti-correlated temporal dynamics) between the right fronto-parietal and limbic resting state net-works is associated with greater self-control and later substance use onset in adolescents. These findings increase our understanding of the developmental importance of prefrontal-limbic circuitry for adolescent substance use at the resting-state network level.8 pagesapplication/pdfen-USCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 InternationalAdolescenceRisk-taking behaviorResting-state fMRIIndependent component analysis (ICA)Fronto-parietal network (FPN)Limbic networkIntrinsic network connectivityNegative functional coupling between the right fronto-parietal and limbic resting state networks predicts increased self-control and later substance use onset in adolescenceArticle - RefereedDevelopmental Cognitive Neurosciencehttps://doi.org/10.1016/j.dcn.2016.06.00220