Menden, Michael P.Wang, DennisMason, Mike J.Szalai, BenceBulusu, Krishna C.Guan, YuanfangYu, ThomasKang, JaewooJeon, MinjiWolfinger, RussNguyen, TinZaslavskiy, MikhailJang, In SockGhazoui, ZaraAhsen, Mehmet ErenVogel, RobertNeto, Elias ChaibubNorman, TheaTang, Eric K. Y.Garnett, Mathew J.Di Veroli, Giovanni Y.Fawell, StephenStolovitzky, GustavoGuinney, JustinDry, Jonathan R.Saez-Rodriguez, JulioAbante, JordiAbecassis, Barbara SchmitzAben, NanneAghamirzaie, DelasaAittokallio, TeroAkhtari, Farida S.Al-lazikani, BissanAlam, TanvirAllam, AminAllen, Chadde Almeida, Mariana PelicanoAltarawy, DoaaAlves, ViniciusAmadoz, AliciaAnchang, BenedictAntolin, Albert A.Ash, Jeremy R.Romeo Aznar, VictoriaBa-alawi, WailBagheri, MoeenBajic, VladimirBall, GordonBallester, Pedro J.Baptista, DeloraBare, ChristopherBateson, MathildeBender, AndreasBertrand, DenisWijayawardena, BhagyaBoroevich, Keith A.Bosdriesz, EvertBougouffa, SalimBounova, GerganaBrouwer, ThomasBryant, BarbaraCalaza, ManuelCalderone, AlbertoCalza, StefanoCapuzzi, StephenCarbonell-Caballero, JoseCarlin, DanielCarter, HannahCastagnoli, LuisaCelebi, RemziCesareni, GianniChang, HyeokyoonChen, GuocaiChen, HaoranChen, HuiyuanCheng, LijunChernomoretz, ArielChicco, DavideCho, Kwang-HyunCho, SunghwanChoi, DaeseonChoi, JaejoonChoi, KwanghunChoi, MinsooDe Cock, MartineCoker, ElizabethCortes-Ciriano, IsidroCserzo, MiklosCubuk, CankutCurtis, ChristinaVan Daele, DriesDang, Cuong C.Dijkstra, TjeerdDopazo, JoaquinDraghici, SorinDrosou, AnastasiosDumontier, MichelEhrhart, FriederikeEid, Fatma-ElzahraaElHefnawi, MahmoudElmarakeby, Haitham A.van Engelen, BoEngin, Hatice Billurde Esch, IwanEvelo, ChrisFalcao, Andre O.Farag, SherifFernandez-Lozano, CarlosFisch, KathleenFlobak, AsmundFornari, ChiaraForoushani, Amir B. K.Fotso, Donatien ChedomFourches, DenisFriend, StephenFrigessi, ArnoldoGao, FengGao, XiaotingGerold, Jeffrey M.Gestraud, PierreGhosh, SamikGillberg, JussiGodoy-Lorite, AntoniaGodynyuk, LizzyGodzik, AdamGoldenberg, AnnaGomez-Cabrero, DavidGonen, Mehmetde Graaf, ChrisGray, HarryGrechkin, MaximGuimera, RogerGuney, EmreHaibe-Kains, BenjaminHan, YounghyunHase, TakeshiHe, DiHe, LiyeHeath, Lenwood S.Hellton, Kristoffer H.Helmer-Citterich, ManuelaHidalgo, Marta R.Hidru, DanielHill, Steven M.Hochreiter, SeppHong, SeungpyoHovig, EivindHsueh, Ya-ChihHu, ZhiyuanHuang, Justin K.Huang, R. StephanieHunyady, LaszloHwang, JinseubHwang, Tae HyunHwang, WoochangHwang, YongdeukIsayev, OlexandrWalk, Oliver Bear Don'tJack, JohnJahandideh, SamadJi, JiadongJo, YousangKamola, Piotr J.Kanev, Georgi K.Karacosta, LoukiaKarimi, MostafaKaski, SamuelKazanov, MaratKhamis, Abdullah M.Khan, Suleiman AliKiani, Narsis A.Kim, AllenKim, JinhanKim, JuntaeKim, KiseongKim, KyungKim, SunkyuKim, YongsooKim, YunseongKirk, Paul D. W.Kitano, HiroakiKlambauer, GunterKnowles, DavidKo, MelissaKohn-Luque, AlvaroKooistra, Albert J.Kuenemann, Melaine A.Kuiper, MartinKurz, ChristophKwon, Mijinvan Laarhoven, TwanLaegreid, AstridLederer, SimoneLee, HeewonLee, JeonLee, Yun WooLeppaho, EemeliLewis, RichardLi, JingLi, LangLiley, JamesLim, Weng KhongLin, ChiehLiu, YiyiLopez, YosvanyLow, JoshuaLysenko, ArtemMachado, DanielMadhukar, NeelDe Maeyer, DriesMalpartida, Ana BelenMamitsuka, HiroshiMarabita, FrancescoMarchal, KathleenMarttinen, PekkaMason, DanielMazaheri, AlirezaMehmood, ArfaMehreen, AliMichaut, MagaliMiller, Ryan A.Mitsopoulos, CostasModos, DezsoVan Moerbeke, MarijkeMoo, KeaganMotsinger-Reif, AlisonMovva, RajivMuraru, SebastianMuratov, EugeneMushthofa, MushthofaNagarajan, NiranjanNakken, SigveNath, AritroNeuvial, PierreNewton, RichardNing, ZhengDe Niz, CarlosOliva, BaldoOlsen, CatharinaPalmeri, AntonioPanesar, BhawanPapadopoulos, StavrosPark, JaesubPark, SeonyeongPark, SungjoonPawitan, YudiPeluso, DanielePendyala, SriramPeng, JianPerfetto, LiviaPirro, StefanoPlevritis, SylviaPoliti, ReginaPoon, HoifungPorta, EduardPrellner, IsakPreuer, KristinaAngel Pujana, MiguelRamnarine, RicardoReid, John E.Reyal, FabienRichardson, SylviaRicketts, CamirRieswijk, LindaRocha, MiguelRodriguez-Gonzalvez, CarmenRoell, KyleRotroff, Danielde Ruiter, Julian R.Rukawa, PloySadacca, BenjaminSafikhani, ZhalehSafitri, FitaSales-Pardo, MartaSauer, SebastianSchlichting, MoritzSeoane, Jose A.Serra, JordiShang, Ming-MeiSharma, AlokSharma, HariShen, YangShiga, MotokiShin, MoonshikShkedy, ZivShopsowitz, KevinSinai, SamSkola, DylanSmirnov, PetrSoerensen, Izel FourieSoerensen, PeterSong, Je-HoonSong, Sang OkSoufan, OthmanSpitzmueller, AndreasSteipe, BorisSuphavilai, ChayapornTamayo, Sergio PulidoTamborero, DavidTang, JingTanoli, Zia-ur-RehmanTarres-Deulofeu, MarcTegner, JesperThommesen, LivTonekaboni, Seyed Ali MadaniTran, Hong T.De Troyer, EwoudTruong, AmyTsunoda, TatsuhikoTuru, GaborTzeng, Guang-YoVerbeke, LievenVidela, SantiagoVis, DanielVoronkov, AndreyVotis, KonstantinosWang, AshleyWang, Hong-Qiang HoraceWang, Po-WeiWang, ShengWang, WeiWang, XiaochenWang, XinWennerberg, KristerWernisch, LorenzWessels, Lodewykvan Westen, Gerard J. P.Westerman, Bart A.White, Simon RichardWillighagen, EgonWurdinger, TomXie, LeiXie, ShuilianXu, HuaYadav, BhagwanYau, ChristopherYeerna, HuwateYin, Jia WeiYu, MichaelYu, MinHwanYun, So JeongZakharov, AlexeyZamichos, AlexandrosZanin, MassimilianoZeng, LiZenil, HectorZhang, FrederickZhang, PengyueZhang, WeiZhao, HongyuZhao, LanZheng, WenjinZoufir, AzedineZucknick, Manuela2019-07-302019-07-302019-06-172041-17232674http://hdl.handle.net/10919/92046The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca's large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.enCreative Commons Attribution 4.0 InternationalArticle - Refereedhttps://doi.org/10.1038/s41467-019-09799-21031209238