Shah, VirajHusain, HyderBankole, AdegbengaKazmi, TaskeenGreear, EmmaHenderson, Carl2023-06-082023-06-082023-05-012767-7672http://hdl.handle.net/10919/115377Hyperviscosity syndrome (HVS) is a rare complication of bothmonoclonal and polyclonal disorders associated with elevation of immunoglobulins. Here, we describe a female patient who presented with shortness of breath and a history of seropositive rheumatoid arthritis with deformities, significant barriers to care, and poor therapeutic adherence. Her rheumatoid factor titer was greater than 1000 kIU/L, and she had an elevated serum viscosity level with her presentation consistent with HVS which improved significantly after therapeutic plasmapheresis. Our case highlights the presentation of rare but potentially life-threatening HVS that can occur in patients with systemic autoimmune rheumatic disorder.application/pdfenCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 InternationalArticle - Refereed2023-06-08https://doi.org/10.7326/aimcc.2022.129125Bankole, Adegbenga [0000-0001-6464-5367]Husain, Hyder [0000-0002-6444-7421]2767-7664