Kishida, Kenneth T.Sandberg, Stefan G.Lohrenz, TerryComair, Youssef G.Sáez, IgnacioPhillips, Paul E. M.Montague, P. Read2017-09-082017-09-082011-08-04http://hdl.handle.net/10919/78842Fast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the feasibility of making sub-second measurements of dopamine release in the caudate nucleus of a human subject during brain surgery. First, we describe the modification of our electrodes that allow for measurements to be made in a human brain. Next, we demonstrate in vitro and in vivo, that our modified electrodes can measure stimulated dopamine release in a rat brain equivalently to previously determined rodent electrodes. Finally, we demonstrate acute measurements of dopamine release in the caudate of a human patient during DBS electrode implantation surgery. The data generated are highly amenable for future work investigating the relationship between dopamine levels and important decision variables in human decisionmaking tasks.application/pdfen-USCreative Commons CC0 1.0 Universal Public Domain DedicationArticle - Refereedhttps://doi.org/10.1371/journal.pone.002329168