Chen, ChenghaoAgrawal, SwetaMark, BrandonMamiya, AkiraSustar, AnnePhelps, Jasper S.Lee, Wei-Chung AllenDickson, Barry J.Card, Gwyneth M.Tuthill, John C.2024-02-022024-02-022021-10-110960-9822S0960-9822(21)01275-6 (PII)https://hdl.handle.net/10919/117826To effectively control their bodies, animals rely on feedback from proprioceptive mechanosensory neurons. In the Drosophila leg, different proprioceptor subtypes monitor joint position, movement direction, and vibration. Here, we investigate how these diverse sensory signals are integrated by central proprioceptive circuits. We find that signals for leg joint position and directional movement converge in second-order neurons, revealing pathways for local feedback control of leg posture. Distinct populations of second-order neurons integrate tibia vibration signals across pairs of legs, suggesting a role in detecting external substrate vibration. In each pathway, the flow of sensory information is dynamically gated and sculpted by inhibition. Overall, our results reveal parallel pathways for processing of internal and external mechanosensory signals, which we propose mediate feedback control of leg movement and vibration sensing, respectively. The existence of a functional connectivity map also provides a resource for interpreting connectomic reconstruction of neural circuits for leg proprioception.21 page(s)application/pdfenCreative Commons Attribution 4.0 InternationalDrosophilacalcium imagingmotor controlneural circuitsoptogeneticsproprioceptionventral nerve cordAnimalsDrosophilaProprioceptionMovementSensory Receptor CellsArticle - Refereedhttps://doi.org/10.1016/j.cub.2021.09.0353123Agrawal, Sweta [0000-0003-0547-4099]346377491879-0445