Detsika, Maria G.Lianos, Elias A.2021-06-112021-06-112021-0160http://hdl.handle.net/10919/103787Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of carbon monoxide (CO). Recent studies uncovered a new cytoprotective role for heme oxygenase-1 (HO-1) by identifying a regulatory role on the complement control protein decay-accelerating factor. This is a key complement regulatory protein preventing dysregulation or overactivation of complement cascades that can cause kidney injury. Cell-specific targeting of HO-1 induction may, therefore, be a novel approach to attenuate complement-dependent forms of kidney disease.application/pdfenCreative Commons Attribution 4.0 Internationalhemeheme oxygenase-1 (HO-1)complementkidney injuryArticle - Refereedhttps://doi.org/10.3390/antiox10010060101334189342076-3921