Robust and Transparent Silver Oxide Coating Fabricated at Room Temperature Kills Clostridioides difficile Spores, MRSA, and Pseudomonas aeruginosa

Hosseini, MohsenHuang, JingeWilliams, Myra D.Gonzalez, Gerardo AlexanderJiang, XiupingFalkinham, Joseph O.Ducker, William A.2024-02-012024-02-012023-12-31Hosseini, M.; Huang, J.; Williams, M.D.; Gonzalez, G.A.; Jiang, X.; Falkinham, J.O., III; Ducker, W.A. Robust and Transparent Silver Oxide Coating Fabricated at Room Temperature Kills Clostridioides difficile Spores, MRSA, and Pseudomonas aeruginosa. Microorganisms 2023, 12, 83.https://hdl.handle.net/10919/117798Antimicrobial coatings can inhibit the transmission of infectious diseases when they provide a quick kill that is achieved long after the coating application. Here, we describe the fabrication and testing of a glass coating containing Ag2O microparticles that was prepared from sodium silicate at room temperature. The half-lives of both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa on this coating are only 2–4 min. The half-life of Clostridioides difficile spores is about 9–12 min, which is extremely short for a spore. Additional tests on MRSA demonstrate that the coating retains its antimicrobial activity after abrasion and that an increased loading of Ag2O leads to a shorter half-life. This coating combines the properties of optical transparency, robustness, fast kill, and room temperature preparation that are highly desirable for an antimicrobial coating.application/pdfenCreative Commons Attribution 4.0 InternationaltransparentcoatingrobustsilverAg2OantibacterialantimicrobialbacteriasporeRobust and Transparent Silver Oxide Coating Fabricated at Room Temperature Kills Clostridioides difficile Spores, MRSA, and Pseudomonas aeruginosaArticle - Refereed2024-01-26Microorganismshttps://doi.org/10.3390/microorganisms12010083