Seo, DongminPaek, Sung-HoOh, SangwooSeo, SungkyuPaek, Se-Hwan2017-09-202017-09-202016-09-24Seo, D.; Paek, S.-H.; Oh, S.; Seo, S.; Paek, S.-H. A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor. Sensors 2016, 16, 1581.http://hdl.handle.net/10919/79293The incidence of diabetes is continually increasing, and by 2030, it is expected to have increased by 69% and 20% in underdeveloped and developed countries, respectively. Therefore, glucose sensors are likely to remain in high demand in medical device markets. For the current study, we developed a needle-type bio-layer interference (BLI) sensor that can continuously monitor glucose levels. Using dialysis procedures, we were able to obtain hypoglycemic samples from commercial human serum. These dialysis-derived samples, alongside samples of normal human serum were used to evaluate the utility of the sensor for the detection of the clinical interest range of glucose concentrations (70–200 mg/dL), revealing high system performance for a wide glycemic state range (45–500 mg/dL). Reversibility and reproducibility were also tested over a range of time spans. Combined with existing BLI system technology, this sensor holds great promise for use as a wearable online continuous glucose monitoring system for patients in a hospital setting.application/pdfenCreative Commons Attribution 4.0 Internationalcontinuous glucose monitoringcompetitive assayglucose dialysis methodbio-layer interferometryneedle-type sensorArticle - Refereed2017-09-20https://doi.org/10.3390/s16101581