Berg, Michael Arthur George2014-03-142014-03-141992-10-06etd-10032007-171522http://hdl.handle.net/10919/39548Isoquinoline alkaloids and analogs play an important role in today's pharmaceutical industry. The need to synthesize single stereoisomers of these alkaloids is important. Many times only a single stereoisomer exhibits the desired activity, while other stereoisomers of the alkaloid exhibit undesired side effects. The stereoselective synthesis of 1, 1-disubstituted 1,2,3,4- tetrahydroisoquinolines using Reissert compound chemistry containing chiral acyl auxiliaries was studied with the ultimate goal of synthesizing spirobenzylisoquinoline alkaloids.xiii, 267 leavesBTDapplication/pdfenIn CopyrightLD5655.V856 1992.B3985IsoquinolineTetrahydroisoquinolinesDissertationhttp://scholar.lib.vt.edu/theses/available/etd-10032007-171522/