Leung, Jacqueline M.Rojas, Julio C.Sands, Laura P.Chan, BrandonRajbanshi, BinitaDu, ZhiyuanDu, Pang2025-02-072025-02-072024-02-122162-3279PMC10861352https://hdl.handle.net/10919/124535Background: Postoperative delirium is prevalent in older adults and has been shown to increase the risk of long-term cognitive decline. Plasma biomarkers to identify the risk for postoperative delirium and the risk of Alzheimer's disease and related dementias are needed. Methods: This biomarker discovery case–control study aimed to identify plasma biomarkers associated with postoperative delirium. Patients aged ≥65 years undergoing major elective noncardiac surgery were recruited. The preoperative plasma proteome was interrogated with SOMAmer-based technology targeting 1433 biomarkers. Results: In 40 patients (20 with vs. 20 without postoperative delirium), a preoperative panel of 12 biomarkers discriminated patients with postoperative delirium with an accuracy of 97.5%. The final model of five biomarkers delivered a leave-one-out cross-validation accuracy of 80%. Represented biological pathways included lysosomal and immune response functions. Conclusion: In older patients who have undergone major surgery, plasma SOMAmer proteomics may provide a relatively non-invasive benchmark to identify biomarkers associated with postoperative delirium.9 page(s)application/pdfenCreative Commons Attribution 4.0 Internationalbiomarkerspostoperative deliriumproteomicsHumansDeliriumPostoperative ComplicationsCase-Control StudiesProteomicsAgedBiomarkersEmergence DeliriumArticle - Refereedhttps://doi.org/10.1002/brb3.3422142Sands, Laura [0000-0003-2446-4486]Du, Pang [0000-0003-1365-4831]383467172162-3279