2016-08-242016-08-242001-07-17http://hdl.handle.net/10919/72432An isolated DNA sequence which regulates the expression of a heterologous gene composed of a mouse whey acidic protein promoter having a length of greater than about 2.4 kb extending upstream from the unique KpnI site in the mouse whey acidic protein gene is disclosed. Specifically a mouse whey acidic protein promoter of about 4.1-4.2 kb in length extending upstream from the unique KpnI site is preferred. This mouse whey acid protein promoter is operably linked to a DNA sequence encoding a heterologous polypeptide and used to prepare transgenic non-human mammals expressing the heterologous polypeptide in their milk. Particularly efficient expression of both cDNAs and genomic DNAs encoding heterologous polypeptides was obtained in transgenic non-human mammals using this promoter, known as the long whey acidic protein promoter.application/pdfen-USPatenthttp://pimg-fpiw.uspto.gov/fdd/36/623/062/0.pdf9321831536/24.1800/14800/7800/15800/16800/17800/18A01K67/0275A01K2207/15A01K2217/00A01K2217/05A01K2227/10A01K2227/105A01K2227/108A01K2267/01A61K38/00C07K14/75C07K2319/00C07K2319/02C12N15/8509C12N9/6464C12Y304/21069C12N2830/0086262336