Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Tehrani, Zahra R.Habibzadeh, ParhamFlinko, RobinChen, HegangAbbasi, AbdolrahimYared, Jean A.Ciupe, Stanca M.Lewis, George K.Sajadi, Mohammad M.2025-01-092025-01-092024-02-140022-18997606721 (PII)https://hdl.handle.net/10919/124004Generation of a stable long-lived plasma cell (LLPC) population is the sine qua non of durable antibody responses after vaccination or infection. We studied 20 individuals with a prior coronavirus disease 2019 infection and characterized the antibody response using bone marrow aspiration and plasma samples. We noted deficient generation of spike-specific LLPCs in the bone marrow after severe acute respiratory syndrome coronavirus 2 infection. Furthermore, while the regression model explained 98% of the observed variance in anti-tetanus immunoglobulin G levels based on LLPC enzyme-linked immunospot assay, we were unable to fit the same model with anti-spike antibodies, again pointing to the lack of LLPC contribution to circulating anti-spike antibodies.application/pdfenCreative Commons Attribution 4.0 InternationalCOVID-19SARS-CoV-2humoral immunityimmunological memoryplasma cellsHumansCOVID-19Plasma CellsSpike Glycoprotein, CoronavirusAntibodies, ViralSARS-CoV-2MaleMiddle AgedFemaleBone MarrowAdultImmunoglobulin GAgedDeficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 InfectionArticle - RefereedThe Journal of Infectious Diseaseshttps://doi.org/10.1093/infdis/jiad6032301Ciupe, Mihaela [0000-0002-5386-6946]383654411537-6613