Mercer, Melissa A.Davis, Jennifer L.McKenzie, Harold C.2023-05-152023-05-152023-05-10Mercer, M.A.; Davis, J.L.; McKenzie, H.C. The Clinical Pharmacology and Therapeutic Evaluation of Non-Steroidal Anti-Inflammatory Drugs in Adult Horses. Animals 2023, 13, 1597.http://hdl.handle.net/10919/115040This review firstly examines the underlying pathophysiology of pain and inflammation associated with orthopedic disease and endotoxemia. Then, it reviews the clinical pharmacology (pharmacokinetics and pharmacodynamics) of both conventional and non-conventional NSAIDs in the adult horse, and finally provides an overview of different modalities to evaluate the therapeutic efficacy of NSAIDs in research.application/pdfenCreative Commons Attribution 4.0 InternationalNSAIDshorsesclinical pharmacologyendotoxemiaosteoarthritisArticle - Refereed2023-05-12https://doi.org/10.3390/ani13101597