White, BakerCarvallo-Chaigneau, Francisco R.Cecere, Thomas E.Mckenzie, HaroldMenciotti, GiulioUmaña Sedó, Sebastián G.2025-09-122025-09-122025-08-30White, B.; Carvallo-Chaigneau, F.R.; Cecere, T.E.; Mckenzie, H.; Menciotti, G.; Umaña Sedó, S.G. Double-Outlet Right Ventricular Malformation in a Two-Year-Old Aberdeen Angus Cow. Animals 2025, 15, 2550.https://hdl.handle.net/10919/137749A 2-year-old Aberdeen Angus cow was presented with lethargy and decreased appetite at the VA-MD College of Veterinary Medicine Large Animal Teaching Hospital. Initial clinical examination revealed cyanosis, tachycardia, polycythemia, and a significant increase in lactate levels. The heifer experienced spontaneous death while hospitalized, prompting a postmortem examination. Gross evaluation demonstrated that the aorta arose entirely from the right ventricle, while the main pulmonary artery maintained its normal position, consistent with a diagnosis of double-outlet right ventricle. Additional cardiac abnormalities were identified, including an atrial septal defect, ventricular septal defect and marked right ventricular hypertrophy. These defects fall under the category of double-outlet right ventricle malformation. While congenital heart defects are a more recognized cause of cardiac failure and mortality in calves, they should remain a consideration in cases of sudden death, even in adult cattle.application/pdfenCreative Commons Attribution 4.0 Internationalcongenitalheart defectpulmonary hypertensionventricular septal defectbovineArticle - Refereed2025-09-12https://doi.org/10.3390/ani15172550