Eaton, A. L.Rakotondraibe, L. HarinantenainaBrodie, P. J.Goetz, M.Kingston, David G. I.2017-01-252017-01-252015-07-010163-3864http://hdl.handle.net/10919/74417Investigation of a DCM extract of the bark of Pleiogynium timoriense from the former Merck collection of natural product extracts for antiproliferative activity indicated that it was active with an IC₅₀ value of 1.3 g/mL against the A2780 ovarian cancer cell line. Bioassay-directed fractionation of this extract yielded the three new bioactive trihydroxyalkylcyclohexenones 1-3. Their structures were determined by a combination of spectroscopic and chemical methods. Compounds 1-3 exhibited submicromolar antiproliferative activity against the A2780 human ovarian cancer cell line, with IC₅₀ values of 0.8, 0.7, and 0.8 M, respectively.1752 - 1755 (4) page(s)application/pdfenIn CopyrightPlant SciencesChemistry, MedicinalPharmacology & PharmacySCYPHOSTATINFRUITSACIDSArticle - Refereedhttps://doi.org/10.1021/acs.jnatprod.5b00119787