Nobari, HadiGandomani, Elham EyniReisi, JalilVahabidelshad, ReyhanehSuzuki, KatsuhikoVolpe, Stella L.Pérez-Gómez, Jorge2022-02-112022-02-112022-01-26Nobari, H.; Gandomani, E.E.; Reisi, J.; Vahabidelshad, R.; Suzuki, K.; Volpe, S.L.; Pérez-Gómez, J. Effects of 8 Weeks of High-Intensity Interval Training and Spirulina Supplementation on Immunoglobin Levels, Cardio-Respiratory Fitness, and Body Composition of Overweight and Obese Women. Biology 2022, 11, 196.http://hdl.handle.net/10919/108301Our study examined the effect of 8 weeks of high-intensity interval training (HIIT) and spirulina supplementation on the humoral immunity, cardio-respiratory fitness, and body composition of overweight and obese women. Thirty sedentary women (height: 161.7 &plusmn; 2.8 cm, body mass: 75.8 &plusmn; 8.4 kg, body mass index [BMI]: 28.8 &plusmn; 2.5 kg/m², age: 25.1 &plusmn; 6.7 years) were divided into three groups: placebo with HIIT group, spirulina group (SG), or combined group (CG). Exercise groups performed HIIT for 8 weeks, with three sessions per week and four to seven repetitions in each session of 30 s running and 30 s walking; the intensity was established at 90% of the maximum heart rate. Supplementation groups received 6 g of spirulina powder per day. Fasting blood samples were collected before and after 8 weeks to determine the concentrations of immunoglobulins (IgA and IgG). There was a significant group-by-time interaction for fat free mass (FFM; <i>p</i> = 0.001, f = 8.52, &eta;p² = 0.39) and IgA (<i>p</i> = 0.036, f = 3.86, &eta;p² = 0.22). The post hoc analysis revealed that CG reduced FFM significantly (<i>p</i> = 0.012, <i>g</i> = &minus;0.55) after training. CG and SG showed significantly greater IgA concentrations after 8 weeks (<i>p</i> = 0.02, <i>g</i> = 0.70 and <i>p</i> = 0.001, <i>g</i> = 0.34, respectively). We conclude that spirulina supplementation with HIIT affects the body composition (lower FFM) but also boosts IgA, which plays an important role in the immune system.application/pdfenCreative Commons Attribution 4.0 Internationalantioxidantbody fatIgAimmunomodulationnutritional supplementobesityphysical activityArticle - Refereed2022-02-11https://doi.org/10.3390/biology11020196