Baker, BiancaGeng, ShuoChen, KeqiangDiao, NaYuan, RuoxiXu, XiguangDougherty, SeanStephenson, CarolineXiong, HuabaoChu, Hong WeiLi, Liwu2021-04-262021-04-262015-01-13http://hdl.handle.net/10919/103122Background: Super-low-dose endotoxemia contributes to cell stress and low-grade inflammation. Results: Super-low-dose LPS removed Tollip from late endosomes/lysosomes and blocked lysosome fusion with endosomes or autophagosomes. Tollip knock-out mice had impaired wound healing. Conclusion: Super-low-dose LPS leads to cell stress through clearing Tollip and blocking lysosome fusion. Significance: Our data reveal molecular dynamics of innate immunity regulation.application/pdfenAttribution 4.0 InternationalArticle - Refereedhttps://doi.org/10.1074/jbc.M114.61144229010