Virginia Tech. Department of ChemistryAteneo de Manila University. Department of ChemistryXavier University - Ateneo de Cagayan University. Department of ChemistryCarreon, Analyn C.Santos, Webster L.Matson, John B.So, Regina C.2015-04-202015-04-202013-09-23Carreon, A. C., Santos, W. L., Matson, J. B., & So, R. C. (2014). Cationic polythiophenes as responsive DNA-binding polymers. Polymer Chemistry, 5(2), 314-317. doi: 10.1039/C3PY01069D1759-9954http://hdl.handle.net/10919/51694A new water soluble cationic polythiophene derivative, poly(N,N,N-trimethyl-3-(2-(thiophen-3-yl)acetamido)propan-1-aminium iodide), was synthesized via two consecutive post-polymerization functionalizations of poly(methyl 2-(thiophen-3-yl)acetate). This conjugated polymer binds DNA at N/P = 5 and forms polyplexes at N/P = 10. Its potential use as a theranostic gene delivery vehicle is investigated here.application/pdfapplication/pdfen-USCreative Commons Attribution-NonCommercial 3.0 UnportedCationic polythiophenesGene delivery vectorsNanoparticlesConjugated polymersArticle - Refereedhttp://pubs.rsc.org/en/content/articlelanding/2014/py/c3py01069dhttps://doi.org/10.1039/C3PY01069D