Bertke, Andrea S.Ma, AyeAyeMargolis, Mathew S.Margolis, Todd P.2017-02-282017-02-282013-03-20http://hdl.handle.net/10919/75202Herpes simplex virus 1 (HSV-1) and HSV-2 establish latency in different neuronal subtypes (A5+ and KH10+) in murine trigeminal ganglia, results which correlate with restricted productive infection in these neurons in vitro. HSV-2 latency-associated transcript (LAT) contains a cis-acting regulatory element near the transcription start site that promotes productive infection in A5+ neurons and a second element in exon 1 that inhibits productive infection in KH10+ neurons. HSV-1 contains no such regulatory sequences, demonstrating different mechanisms for regulating productive HSV infection in neurons.application/pdfenIn CopyrightArticle - Refereedhttps://doi.org/10.1128/JVI.00383-13Bertke, Andrea S. [0000-0002-8941-8010]