Zhang, JiantaoWu, ChaochenSheng, JiayuanFeng, Xueyang2017-05-012017-05-012016-03-181742-206Xhttp://hdl.handle.net/10919/77563We report for the first time that 5-hydroxytryptophan can be synthesized in Saccharomyces cerevisiae by heterologously expressing prokaryotic phenylalanine 4-hydroxylase or eukaryotic tryptophan 3/5-hydroxylase, together with enhanced synthesis of MH4 or BH4 cofactors. The innate DFR1 gene in the folate synthesis pathway was found to play pivotal roles in 5-hydroxytryptophan synthesis.1432-1435application/pdfenCreative Commons Attribution-NonCommercial 3.0 UnportedArticle - RefereedZhang, JiantaoWu, ChaochenSheng, JiayuanFeng, Xueyanghttps://doi.org/10.1039/c5mb00888c1251742-2051