Xu, Zhibing2014-03-142014-03-142010-09-30etd-10132010-152742http://hdl.handle.net/10919/35376Paclitaxel is one of the most successful anti-cancer drugs, particularly in the treatment of breast cancer and ovarian cancer. For the investigation of the interaction between paclitaxel and MD-2 protein, and development of new antagonists for lipopolysaccharide, several C10 A-nor-paclitaxel analogs have been synthesized and their biological activities have been evaluated. In order to reduce the myelosuppression effect of the paclitaxel, several C3â ² and C4 paclitaxel analogs have been synthesized and their biological evaluation have been studied.In CopyrightMyelosuppressionbeta-LactamBaccatinInflammation2-MethoxyestradiolTubulinAnticancer DrugsCancerPaclitaxelAntagonistsThesishttp://scholar.lib.vt.edu/theses/available/etd-10132010-152742/