Virginia Tech. Department of Mechanical EngineeringVirginia Tech. Department of Chemical EngineeringUniversity of Kentucky. Department of Chemical EngineeringRobbins, Brian A.Radiom, MiladDucker, William A.Walz, John Y.Paul, Mark R.2015-05-262015-05-262014-10-28Robbins, Brian A., Radiom, Milad, Ducker, William A., Walz, John Y. & Paul, Mark R. (2014). The stochastic dynamics of tethered microcantilevers in a viscous fluid. Journal of Applied Physics, 116(16). doi: 10.1063/1.49005250021-8979http://hdl.handle.net/10919/52621We explore and quantify the coupled dynamics of a pair of micron scale cantilevers immersed in a viscous fluid that are also directly tethered to one another at their tips by a spring force. The spring force, for example, could represent the molecular stiffness or elasticity of a biomolecule or material tethered between the cantilevers. We use deterministic numerical simulations with the fluctuation-dissipation theorem to compute the stochastic dynamics of the cantilever pair for the conditions of experiment when driven only by Brownian motion. We validate our approach by comparing directly with experimental measurements in the absence of the tether which shows excellent agreement. Using numerical simulations, we quantify the correlated dynamics of the cantilever pair over a range of tether stiffness. Our results quantify the sensitivity of the auto-and cross-correlations of equilibrium fluctuations in cantilever displacement to the stiffness of the tether. We show that the tether affects the magnitude of the correlations which can be used in a measurement to probe the properties of an attached tethering substance. For the configurations of current interest using micron scale cantilevers in water, we show that the magnitude of the fluid coupling between the cantilevers is sufficiently small such that the influence of the tether can be significant. Our results show that the cross-correlation is more sensitive to tether stiffness than the auto-correlation indicating that a two-cantilever measurement has improved sensitivity when compared with a measurement using a single cantilever. (C) 2014 AIP Publishing LLC.9 pagesapplication/pdfen-USIn CopyrightViscosityBiomolecular dynamicsAcoustic noise spectraDNAFinite element methodsArticle - Refereedhttp://scitation.aip.org/content/aip/journal/jap/116/16/10.1063/1.4900525https://doi.org/10.1063/1.4900525