Mohamed, Mohamed F.Seleem, Mohamed N.2020-09-212020-09-212014-01-011177-8881dddt-8-1979 (PII)http://hdl.handle.net/10919/100039The therapeutic efficacy of two novel short antimicrobial and anti-inflammatory peptides (RR and RRIKA) was evaluated in a mouse model of staphylococcal skin infection. RR (2%) and RRIKA (2%) significantly reduced the bacterial counts and the levels of proinflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-6, in methicillin-resistant Staphylococcus aureus USA 300-0114 skin lesions. Furthermore, the combined therapy of RRIKA (1%) and lysostaphin (0.5%) had significantly higher antistaphylococcal and anti-inflammatory activity compared to monotherapy. This study supports the potential use of these peptides for topical treatment of methicillin-resistant Staphylococcus aureus skin infections.Pages 1979-19835 page(s)Electronic-eCollectionapplication/pdfenCreative Commons Attribution-NonCommercial 3.0 UnportedLife Sciences & BiomedicineChemistry, MedicinalPharmacology & Pharmacyantimicrobial peptidesMRSAlysostaphinskin infectionmiceIN-VIVOLYSOSTAPHININFLAMMATIONWOUNDSALPHAMRSA1115 Pharmacology and Pharmaceutical SciencesAnimalsMice, Inbred BALB CMiceStaphylococcal Skin InfectionsDisease Models, AnimalAntimicrobial Cationic PeptidesAnti-Inflammatory Agents, Non-SteroidalMicrobial Sensitivity TestsFemaleMethicillin-Resistant Staphylococcus aureusArticle - Refereed2020-09-21https://doi.org/10.2147/DDDT.S721298Seleem, Mohamed [0000-0003-0939-0458]25378910 (pubmed)1177-8881