Virginia Tech. Department of ChemistryCenter for Drug DiscoveryCalifornia State University, Fresno. Department of ChemistryChen, Qiao-HongKingston, David G. I.2015-04-202015-04-202014-06-19Chen, Q.-H., & Kingston, D. G. I. (2014). Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads. Natural Product Reports, 31(9), 1202-1226. doi: 10.1039/C4NP00024B0265-0568http://hdl.handle.net/10919/51703Zampanolide is a marine natural macrolide and a recent addition to the family of microtubule-stabilizing cytotoxic agents. Zampanolide exhibits unique effects on tubulin assembly and is more potent than paclitaxel against several multi-drug resistant cancer cell lines. A high-resolution crystal structure of xB-tubulin in complex with zampanolide explains how taxane-site microtubule-stabilizing agents promote microtubule assemble and stability. This review provides an overview of current developments of zampanolide and its related but less potent analogue dactylolide, covering their natural sources and isolation, structure and conformation, cytotoxic potential, structure_activity studies, mechanism of action, and syntheses.application/pdfen-USCreative Commons Attribution-NonCommercial 3.0 UnportedZampanolideCytotoxic agentsMicrotubule stabilizing agentsMulti-drug resistanceAnti-cancer drugsArticle - Refereedhttp://pubs.rsc.org/en/content/articlelanding/2014/np/c4np00024bhttps://doi.org/10.1039/C4NP00024B