Wynn, Jessica E.Santos, Webster L.2016-03-182016-03-182015-04-28Wynn, J. E., & Santos, W. L. (2015). HIV-1 drug discovery: targeting folded RNA structures with branched peptides. Organic & Biomolecular Chemistry, 13(21), 5848-5858. doi:10.1039/C5OB00589B1477-05202015_Wynn_HIV_1_drug_discovery_targeting_fold.pdfGM093834http://hdl.handle.net/10919/64968Human immunodeficiency virus type 1 (HIV-1) is an RNA virus that is prone to high rates of mutation. While the disease is managed with current antiretroviral therapies, drugs with a new mode of action are needed. A strategy towards this goal is aimed at targeting the native three-dimensional fold of conserved RNA structures. This perspective highlights medium-sized peptides and peptidomimetics used to target two conserved RNA structures of HIV-1. In particular, branched peptides have the capacity to bind in a multivalent fashion, utilizing a large surface area to achieve the necessary affinity and selectivity toward the target RNA.11 pagesapplication/pdfen-USCreative Commons Attribution-NonCommercial 3.0 UnportedArticle - Refereedhttps://doi.org/10.1039/C5OB00589B1321