Ismail, AhmedEl-Sharkawy, IslamSherif, Sherif M.2020-06-302020-06-302020-05-30Ismail, A.; El-Sharkawy, I.; Sherif, S. Salt Stress Signals on Demand: Cellular Events in the Right Context. Int. J. Mol. Sci. 2020, 21, 3918.http://hdl.handle.net/10919/99178Plant stress is a real dilemma; it puzzles plant biologists and is a global problem that negatively affects people’s daily lives. Of particular interest is salinity, because it represents one of the major water-related stress types. We aimed to determine the signals that guide the cellular-related events where various adaptation mechanisms cross-talk to cope with salinity-related water stress in plants. In an attempt to unravel these mechanisms and introduce cellular events in the right context, we expansively discussed how salt-related signals are sensed, with particular emphasis on aquaporins, nonselective cation channels (NSCCs), and glycosyl inositol phosphorylceramide (GIPC). We also elaborated on the critical role Ca2⁺, H⁺, and ROS in mediating signal transduction pathways associated with the response and tolerance to salt stress. In addition, the fragmentary results from the literature were compiled to develop a harmonized, informational, and contemplative model that is intended to improve our perception of these adaptative mechanisms and set a common platform for plant biologists to identify intriguing research questions in this area.application/pdfenCreative Commons Attribution 4.0 Internationalsalinityosmotic and ionic stresssalt-related signalsadaptive cellular responsesaquaporinsNSCCsGIPCFERONIACa2+H+ROSArticle - Refereed2020-06-30https://doi.org/10.3390/ijms21113918