Wallace, Dory A.Trucks, Mary RebekahDeLuca, Stephanie C.2025-03-132025-03-132024-11https://hdl.handle.net/10919/124851This work was internally funded by the Fralin Biomedical Research Institute Neuromotor Research Clinic (FBRINMRC).Objective: To report practice based evidence built on clinical findings where an intensive therapeutic approach called ACQUIRE Therapy was used as a rehabilitation/habilitation tool for children diagnosed with CASK mutations. ACQUIRE Therapy delivery is based on principles of learning and guided by a therapeutic framework often used in the delivery of intensive therapy. Design: Clinical Cohort. Setting: Natural environments (e.g., home-like environment). Participants: A total of 20 females, 12 to 128 months, mean age = 44.75 (SD = 31.64). Intervention: Trained Occupational therapists delivered high-dosage rehabilitation for an average of 64.06 hours (SD = 12.91) across 4 weeks. ACQUIRE Therapy targeted cross-domain intervention targets often associated with executive control and praxis. Main outcome measures: Clinical data was examined from the following sources; therapist daily treatment documentation (eg, therapy goals, video recordings, daily therapy logs, and discharge documentation). Results: Receptive communication improved in all children. The most common motor skill improvements occurred in trunk control occurring in 33% of children; followed by, gross reaching abilities in 21% of children; fine-motor skills in 19%; head control in 15%; and mobility in 12%. Documentation of cognitive-motor pairing of skills was documented in all children. Conclusions: Diagnosis specific intervention targets (eg, attention and cognitive-pairing skills) need to be considered when providing therapeutic services to children with CASK-gene mutations and other forms of Global Developmental Delay.application/pdfenCreative Commons Attribution-NonCommercial 4.0 InternationalCASK-gene mutationmicrocephalyACQUIRE therapyIntensive therapyintensive rehabilitationglobal developmental delayArticle - Refereedhttps://doi.org/10.1177/2753635124130285213