Beck, Patrick J.Benfield, JohnMorales, Joshua2023-07-102023-07-102023-06-29Patrick J. Beck, John Benfield, and Joshua Morales, “Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI,” Case Reports in Hematology, vol. 2023, Article ID 5926340, 4 pages, 2023. doi:10.1155/2023/5926340http://hdl.handle.net/10919/115705Factor XII (FXII) deficiency is a rare coagulopathy that typically goes undiagnosed due to the lack of abnormal bleeding or thrombosis. However, the accompanying prolonged activated partial thromboplastin time (aPTT) can create difficulties with maintaining therapeutic anticoagulation in the setting of acute coronary syndrome (ACS). Here, we present the case of a 52-year-old man presenting with chest pain and diagnosed with an NSTEMI but also found with a prolonged baseline aPTT ultimately secondary to FXII deficiency. Here, we discuss the diagnostic work-up of an isolated prolonged aPTT to identify possible etiologies, such as FXII deficiency, and ultimately inform ACS management.application/pdfenCreative Commons Attribution 4.0 InternationalArticle - Refereed2023-07-02Copyright © 2023 Patrick J. Beck et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://doi.org/10.1155/2023/5926340