Edgar, Kevin J.Matson, John B.Meng, Xiangtao2021-03-182021-03-182020-08-11http://hdl.handle.net/10919/102747Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ω-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.In Copyright (InC)This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).Patent2021-03-18Edgar, Kevin [0000-0002-9459-9477]15025451A61K47/38C08B3/16C08B3/00C08B3/14C08B37/0018C08B37/002110738134