Murphy, Quiyana M.Ciupe, Stanca M.2023-02-242023-02-242023-02-13Murphy, Q.M.; Ciupe, S.M. Understanding Neutrophil Dynamics during COVID-19 Infection. Appl. Sci. 2023, 13, 2409.http://hdl.handle.net/10919/113935Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in varied clinical outcomes, with virus-induced chronic inflammation and tissue injury being associated with enhanced disease pathogenesis. To determine the role of tissue damage on immune populations recruitment and function, a mathematical model of innate immunity following SARS-CoV-2 infection has been proposed. The model was fitted to published longitudinal immune marker data from patients with mild and severe COVID-19 disease and key parameters were estimated for each clinical outcome. Analytical, bifurcation, and numerical investigations were conducted to determine the effect of parameters and initial conditions on long-term dynamics. The results were used to suggest changes needed to achieve immune resolution.application/pdfenCreative Commons Attribution 4.0 Internationalmathematical modellingneutrophilsCOVID-19SARS-CoV-2inflammationresolutionbifurcation analysissensitivity analysisArticle - Refereed2023-02-24https://doi.org/10.3390/app13042409