Tyson, John J.Csikasz-Nagy, AttilaGonze, DidierKim, Jae KyoungSantos, SilviaWolf, Jana2022-07-072022-07-072022-04-152042-889820220011http://hdl.handle.net/10919/111153To survive and reproduce, a cell must process information from its environment and its own internal state and respond accordingly, in terms of metabolic activity, gene expression, movement, growth, division and differentiation. These signal-response decisions are made by complex networks of interacting genes and proteins, which function as biochemical switches and clocks, and other recognizable information-processing circuitry. This theme issue of Interface Focus (in two parts) brings together articles on time-keeping and decision-making in living cells-work that uses precise mathematical modelling of underlying molecular regulatory networks to understand important features of cell physiology. Part I focuses on time-keeping: mechanisms and dynamics of biological oscillators and modes of synchronization and entrainment of oscillators, with special attention to circadian clocks.application/pdfenCreative Commons Attribution 4.0 Internationalmolecular regulatory networksfeedback loopsmathematical modellingmulti-rhythmicityentrainmentcircadian rhythmsArticle - Refereedhttps://doi.org/10.1098/rsfs.2022.00111232042-8901