Lanciotti, Robert Arthur2014-03-142014-03-141994-08-05etd-06062008-163955http://hdl.handle.net/10919/38252Phosphorylase kinase (EC 2.7.1.38) is a key enzyme involved in the regulation of the glycogenolysis pathway. It catalyzes the Ca²⁺-dependent phosphorylation and activation of the enzyme glycogen phosphorylase to make the active form glycogen phosphorylase. Phosphorylase kinase is composed of 4 subunits with a stoichiometry of (αβγδ)₄. The γ subunit is the catalytic subunit. The regulatory domain (residues 277-387) of γ contains a sequence resembling the sites phosphorylated in known γ substrates with the exception that a valine₃₃₂ occurs at the analogous position of the phosphorylated serine or threonine residue.xi, 125 leavesBTDapplication/pdfenIn CopyrightLD5655.V856 1994.L363BaculovirusesCalmodulinProtein kinasesDissertationhttp://scholar.lib.vt.edu/theses/available/etd-06062008-163955/