Marlow, ChristineCuoco, Joshua A.Hoggarth, Austin R.Stump, Michael S.Apfel, Lisa S.Rogers, Cara M.2023-09-282023-09-282023-032036-3605PMC1008840910.1177_20363613231168704 (PII)http://hdl.handle.net/10919/116366Diffuse hemispheric glioma, H3 G34-mutant, is a recently recognized distinct high-grade glioma with a dismal prognosis. In addition to the H3 G34 missense mutation, numerous genetic events have been identified in these malignant tumors, including ATRX, TP53, and, rarely, BRAF genes. There are only a few reports to date that have identified BRAF mutations in diffuse hemispheric glioma, H3 G34-mutant. Moreover, to our knowledge, gains of the BRAF locus have yet to be described. Here, we present a case of an 11-year-old male with a diffuse hemispheric glioma, H3 G34-mutant, found to have novel gains of the BRAF locus. Furthermore, we emphasize the current genetic landscape of diffuse hemispheric glioma, H3 G34-mutant, and implications of an aberrant BRAF signaling pathway.7 page(s)application/pdfenCreative Commons Attribution-NonCommercial 4.0 InternationalOncologyDiffuse hemispheric gliomaH3 G34-mutantH3 K27-mutantneuro-oncologypediatricACTIVATION31 Biological Sciences32 Biomedical and Clinical Sciences3105 Genetics3211 Oncology and CarcinogenesisBrain DisordersRare DiseasesNeurosciencesBrain CancerGeneticsCancerArticle - Refereed2023-09-27https://doi.org/10.1177/2036361323116870415370567112036-3613