Adams, D. Q.Alduino, C.Alfonso, K.Avignone, F. T., IIIAzzolini, O.Bari, G.Bellini, F.Benato, G.Beretta, M.Biassoni, M.Branca, A.Brofferio, C.Bucci, C.Camilleri, J.Caminata, A.Campani, A.Cao, J.Capelli, S.Capelli, C.Cappelli, L.Cardani, L.Carniti, P.Casali, N.Celi, E.Chiesa, D.Clemenza, M.Copello, S.Cremonesi, O.Creswick, R. J.D'Addabbo, A.Dafinei, I.Del Corso, F.Dell'Oro, S.Di Domizio, S.Di Lorenzo, S.Dixon, T.Dompe, V.Fang, D. Q.Fantini, G.Faverzani, M.Ferri, E.Ferroni, F.Fiorini, E.Franceschi, M. A.Freedman, S. J.Fu, S. H.Fujikawa, B. K.Ghislandi, S.Giachero, A.Girola, M.Gironi, L.Giuliani, A.Gorla, P.Gotti, C.Guillaumon, P. V.Gutierrez, T. D.Han, K.Hansen, E. V.Heeger, K. M.Helis, D. L.Huang, H. Z.Keppel, G.Kolomensky, Yu G.Kowalski, R.Liu, R.Ma, L.Ma, Y. G.Marini, L.Maruyama, R. H.Mayer, D.Mei, Y.Moore, M. N.Napolitano, T.Nastasi, M.Nones, C.Norman, E. B.Nucciotti, A.Nutini, I.O'Donnell, T.Olmi, M.Oregui, B. T.Ouellet, J. L.Pagan, S.Pagliarone, C. E.Pagnanini, L.Pallavicini, M.Pattavina, L.Pavan, M.Pessina, G.Pettinacci, V.Pira, C.Pirro, S.Pottebaum, E. G.Pozzi, S.Previtali, E.Puiu, A.Quitadamo, S.Ressa, A.Rosenfeld, C.Schmidt, B.Sharma, V.Singh, V.Sisti, M.Speller, D.Stark, P.Surukuchi, P. T.Taffarello, L.Tomei, C.Torres, A.Torres, J. A.Vetter, K. J.Vignati, M.Wagaarachchi, S. L.Welliver, B.Wilson, J.Wilson, K.Winslow, L. A.Zimmermann, S.Zucchelli, S.2025-10-092025-10-092024-12-120031-9007https://hdl.handle.net/10919/138106The Cryogenic Underground Observatory for Rare Events (CUORE) is a detector array comprised by 988 5 cm x 5 cm x 5 cm TeO2 crystals held below 20 mK, primarily searching for neutrinoless doublebeta decay in Te-130. Unprecedented in size among cryogenic calorimetric experiments, CUORE provides a promising setting for the study of exotic throughgoing particles. Using the first tonne year of CUORE's exposure, we perform a search for hypothesized fractionally charged particles (FCPs), which are well-motivated by various standard model extensions and would have suppressed interactions with matter. Across the searched range of charges e/24 - e/2 no excess of FCP candidate tracks is observed over background, setting leading limits on the underground FCP flux with charges e/24 - e/5 at 90% confidence level. Using the low background environment and segmented geometry of CUORE, we establish the sensitivity of tonne-scale subkelvin detectors to diverse signatures of new physics.application/pdfenCreative Commons Attribution 4.0 InternationalArticle - Refereedhttps://doi.org/10.1103/PhysRevLett.133.24180113324397503261079-7114