Cablay, KoryBorowicz, Violet M.Fulton, Ryan2022-03-022022-03-022022-01-281077-411400043426-900000000-96674 (PII)http://hdl.handle.net/10919/1090086-mercaptopurine is a chemotherapeutic drug that exhibits hepatotoxic effects due to its toxic metabolites. This report describes a case of suspected drug-induced liver injury exacerbated by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A 16-year-old male with very high risk B-cell acute lymphoblastic leukemia was admitted for hyperbilirubinemia 2 months after a 6-mercaptopurine dosage increase and found to have an active SARS-CoV-2 infection. Liver function improved throughout hospitalization and the patient was discharged on allopurinol. Following liver function after a dosage increase of hepatoxic chemotherapy and in a pediatric oncology patient with an active SARS-CoV-2 infection undergoing treatment is vital due to potential liver impact.application/pdfenIn Copyright1102 Cardiorespiratory Medicine and HaematologyOncology & CarcinogenesisArticle - Refereed2022-03-02https://doi.org/10.1097/mph.0000000000002407350915181536-3678