Porcine torque teno virus vaccines and diagnosis

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dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.inventorMeng, Xiang-Jinen
dc.contributor.inventorHuang, Yaoweien
dc.date.accessed2019-02-15en
dc.date.accessioned2019-02-26T22:24:01Zen
dc.date.available2019-02-26T22:24:01Zen
dc.date.filed2015-11-19en
dc.date.issued2018-02-20en
dc.description.abstractThe present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes. Finally, the present invention provides methods for diagnosing PTTV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber14946384en
dc.identifier.patentnumber9897605en
dc.identifier.urihttp://hdl.handle.net/10919/87833en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/05/976/098/0.pdfen
dc.language.isoenen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcA61K39/12en
dc.subject.cpcA61K2039/552en
dc.subject.cpcC07K14/005en
dc.subject.cpcC07K16/081en
dc.subject.cpcC12N7/00en
dc.subject.cpcC12Q1/701en
dc.subject.cpcC12N2750/00021en
dc.subject.cpcC12N2750/00022en
dc.subject.cpcC12N2750/00034en
dc.subject.cpcC12N2750/14034en
dc.subject.cpcG01N33/56983en
dc.subject.cpcG01N2333/01en
dc.subject.cpcG01N2333/085en
dc.subject.cpcG01N2469/20en
dc.titlePorcine torque teno virus vaccines and diagnosisen
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen

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