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In today’s society, vaccination is a highly controversial issue drawing all sorts of people into the debate from scientists and physicians to religious leaders and parents. Currently, there are many different arguments for and against vaccination. Interestingly enough, many of these arguments parallel those of the early 20th century. My goal through this research was to analyze how vaccination was framed and represented in American newspapers during the early 20th century (1915-1921). My research suggested that most newspapers framed vaccination in a positive light, with the exception of the occasional skepticism and doubt.