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Communities in VTechWorks
(Virginia Tech, 2019)The university's flagship publication, Virginia Tech Magazine, forges stronger relationships among alumni, donors, and friends of Virginia Tech. The magazine highlights the vibrancy of a university on the leading edge of ...
(Elsevier, 2016-02-24)Cellular homeostasis requires correct delivery of cell-surface receptor proteins (cargo) to their target subcellular compartments. The adapter proteins Tom1 and Tollip are involved in sorting of ubiquitinated cargo in ...
Opening the Debate: How to Fulfill the Need for Physicians’ Training in Circadian-Related Topics in a Full Medical School Curriculum (Ubiquity Press, 2015)Background: Circadian rhythms are daily changes in our physiology and behavior that are manifested as patterns of brain wave activity, periodic hormone production, recurring cell regeneration, and other oscillatory biological ...
Association of the circadian factor Period 2 to p53 influences p53’s function in DNA-damage signaling (American Society for Cell Biology, 2014-11-19)Circadian period proteins influence cell division and death by associating with checkpoint components, although their mode of regulation has not been firmly established. hPer2 forms a trimeric complex with hp53 and its ...
The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells (American Society for Cell Biology, 2014-10-01)Human Period 2 (hPer2) is a transcriptional regulator at the core of the circadian clock mechanism that is responsible for generating the negative feedback loop that sustains the clock. Its relevance to human disease is ...